daily selenium requirement of humans. Wld Rev Nutr Diet 1988;55:98 5. Reeves WC. Marcuard SP, Willis SE, Movahed A. Reversible cardiomyopathy due to selenium deficiency. J Parenter Enteral Nutr 1989;13:663 6. National Academy of Science, Institute of Medicine. "Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids." Http://www.nap.edu/pdf/0309 069351/pdf_image/284.pdf. (Accessed June 6 2000) 7. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning, 2nd ed. Baltimore, MD: Williams & Wilkins, 1997 8. Moreno-Reyes R, Suetens C, Mathieu F, et al. Kashin- Beck osteoarthropathy in rural Tibet in relation to sele- nium and iodine status. N Eng J Med 1998;339:1112- 1120 9. Ip C. Interaction of vitamin C and selenium-induced inhi- bition of angiogenesis in mammary cancer at chemo- preventive levels of intake. Mol Carcinog 1999;26:213- 225 10. Maier RH, Purser SM, Nicholson DL, Pories WJ. "The cytotoxic interaction of inorganic trace elements with EDTA and cisplatin in sensi- tive and resistant human selenium supplementation due to its potential role in CHD, CHF, or perhaps non- cardiovascular conditions, should consider the addition of vitamin E (400 mcg/day) which may actually work synergistically with selenium (3). REFERENCES 1. Neve J. "Selenium as a risk factor for cardiovascular diseases." J Cardiovasc Risk 1996;3(1):42-47 2. Kardinaal AF, Kok FJ, Kohlmeier L, et al. Association between toenail selenium and risk of acute myocardial infarction in European men.  The EURAMIC Study. European Antioxidant Myocardial Infarction and Breast Cancer.  Am J Epidemiol 1997;145:373-9 3. PDR (Physician's Desk Reference) for Nutritional Supplements. 1st  ed. Montvale, New Jersey. Medical Economics Company. 2001:417 4. Yang G, Ge K, Chen J, Chen X. Selenium-related endemic disease and the ovarian cancer cells." In Vitro Cell Dev Biol Anim 1997;33:218-221 11. Natural Medicines com- prehensive Database. 3rd ed. Stockton, CA. Therapeutic Research Faculty. 2000;950 12. Koller LD, Exon JH. "The two faces of selenium- deficiency and toxicity-are similar in animals and man." Can J Vet Res 1986;50(3):297-306 13. Busch F. The New Nutrition: From antioxidants to Zucchini. John Wiley & Sons. New York, NY. 2000 Selenium dosage: • 200 mcg per day is felt to be appropriate • Vitamin E 400 mcg per day may also work synergistically with selenium
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