Antioxidants don't measure up in the latest study of over 20,000 patients Antioxidant vitamins have long been supported for their poten- tial role in the prevention and protection from the development of coronary heart disease(CHD) and with good reason. Oxidation of cholesterol parti- cles allows them to accumulate within the artery walls and ani- mal studies using antioxidants have demonstrated a slowing of the formation of plaque within these vessel walls with the addi- tion of antioxidant vitamins.  In human studies, antioxidant blood levels have been inverse- ly correlated with the incidence and mortality associated with vascular disease such as CHD and stroke.  However, large- scale randomized studies have been lacking and perhaps find- ings so far have only been indicative of an association between a healthy lifestyle and diet. The Heart Protection Study involved 20,536 adults with CHD, other vascular disease or diabetes.  Participants were ran- domly allocated to receive antioxidant vitamin supplemen- tation (600 mg vitamin E, 250 mg vitamin C, and 20 mg beta- carotene daily) or matching placebo.  Over the follow-up period, participants were assessed for heart and vascular related events such as death, heart attack and stroke, as well as non-cardiovascular events such as the development of cancer were recorded. This information certainly places doubt on the benefit of antioxi- dant vitamins in the patient pop- ulation studied.  However, it is important to realize that these individuals either had known car- diovascular disease or were at extremely high risk for its devel- opment.  It has been speculated that perhaps antioxidant vitamins are best utilized in those individ- uals who have not yet developed cardiovascular disease, but are simply at risk for its occurrence. Potentially antioxidants may still play a role in the primary preven- tion of these conditions, and therefore this may be the focus of further research.   However, the current large- scale randomized study sug- gests that antioxidant vita- mins play no significant role in the prevention of further cardiovascular events in indi- viduals with known cardiovas- cular disease or in those who are at high risk. Title:    MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomized placebo-controlled trial Authors: Heart Protection Study Collaborative Group Source: Lancet 2002;360:23-33 Despite a significant rise in the vitamin blood lev- els in participants who received the antioxidant vitamins, there was no observed difference in any of the measured cardiovascular out- comes over a 5 year period.  In addition, there was no difference in the incidence of can- cer or other non-cardio- vascular disorders.
Save this Article in My Holistic Heart Health...

Mail to a friend
Mail to a friend

View a Printer-Friendly version
 
Related articles
Overviews
Summaries
 
Related products
Purchase The New Nutrition: From Antioxidants to Zucchini Add to Shopping List  
Buy it now
 The New Nutrition: F...

Purchase The New Encyclopedia of Vitamins, Minerals, Supplements, & Herbs Add to Shopping List  
Buy it now
 The New Encyclopedia...

Purchase Nutraceuticals: The Complete Encyclopedia of Supplements, Herbs, Vitamins, and Healing Foods Add to Shopping List  
Buy it now
 Nutraceuticals: The ...

Purchase Prescription for Nutritional Healing : A Practical A-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs, and Food Supplements Add to Shopping List  
Buy it now
 Prescription for Nut...

 
Go to page: 1  
 

Related Articles
Overviews
Coronary Heart Disease
Herbs and Alternative Supplements - Heart Help or Hype?
Vitamin C
Vitamin E
Vitamins & Minerals: Shortcut to Better Nutrition and Heart Health?

Summaries
Antioxidants Don’t Measure Up to Zocor and Niacin for the Prevention of Coronary Heart Disease

© Copyright 2001 Holistic Heart Health, Inc. All rights reserved.

THIS SITE DOES NOT PROVIDE MEDICAL ADVICE. This Internet site provides information of a general nature and is for educational purposes only. Always seek the advice of a health care professional if you have a specific health concern. Please review the Terms and Conditions of Use before using this site.